Unraveling the Armor of a Killer: Evasion of Host Defenses by African Swine Fever Virus.
نویسندگان
چکیده
African swine fever is an acute hemorrhagic disease of pigs. Extensive recent spread in the Russian Federation and Eastern Europe has increased the risk to global pig production. The virus is a large DNA virus and is the only member of the Asfarviridae family. In pigs, the virus replicates predominantly in macrophages. We review how the virus overcomes the barriers to replication in the macrophage and the virus mechanism to inhibit key host defense pathways.
منابع مشابه
African swine fever virus controls the host transcription and cellular machinery of protein synthesis.
Throughout a viral infection, the infected cell reprograms the gene expression pattern in order to establish a satisfactory antiviral response. African swine fever virus (ASFV), like other complex DNA viruses, sets up a number of strategies to evade the host's defense systems, such as apoptosis, inflammation and immune responses. The capability of the virus to persist in its natural hosts and i...
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عنوان ژورنال:
- Journal of virology
دوره 91 6 شماره
صفحات -
تاریخ انتشار 2017